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KMID : 1037820150040010001
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Journal of Pain and Autonomic Disorders
2015 Volume.4 No. 1 p.1 ~ p.5
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Role of Anticonvulsants in Treatment of Neuropathic Pain
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이동국:Lee Dong-Kuck
저자없음:No authors listed
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Abstract
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Neuropathic pain (NP) develops as a result of lesions or disease affecting the somatosensory nervous system either in the periphery or centrally. Distressingly frequent characteristics of NP are its poor response to current available treatment and potentially prolonged duration. In adults, the prognosis for recovery from NP is frequently poor, depending somewhat on the source and nature of the underlying nervous tissue injury or abnormality. Both epilepsy and NP are associated with excess neuronal activity, therefore, both may be treated with anticonvulsants to either block excitatory or promote inhibitory mechanisms. Both disorders are associated with differential changes in sodium and calcium channel subunit expression resulting in functional changes. Anticonvulsants drugs have been used in the management of NP since not long after they were introduced for the treatment of epilepsy.
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KEYWORD
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Neuropathic pain, Anticonvulsants
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Listed journal information
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